Nomegestrol

Modify Date: 2024-01-06 11:05:21

Nomegestrol structure	Common Name	Nomegestrol
	CAS Number	58691-88-6	Molecular Weight	328.45
	Density	1.2±0.1 g/cm3	Boiling Point	502.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₈O₃	Melting Point	204-205ºC
	MSDS	N/A	Flash Point	271.8±26.6 °C

Use of Nomegestrol

Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

Name	17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
Synonym	More Synonyms

Description	Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Others
Target	Kd: 5.44 nM (Rat uterine progesterone receptor)[1]
In Vitro	Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a Kd of 5.44 nM for rat uterine progesterone receptor[1]. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity[2].
References	[1]. Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56(6):325-8. [2]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.

Density	1.2±0.1 g/cm3
Boiling Point	502.6±50.0 °C at 760 mmHg
Melting Point	204-205ºC
Molecular Formula	C₂₁H₂₈O₃
Molecular Weight	328.45
Flash Point	271.8±26.6 °C
Exact Mass	328.203857
PSA	54.37000
LogP	2.58
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.574
Storage condition	2~8°C

Risk Phrases	63-50
WGK Germany	3.0

Nomegestrol

(17a)-17-Acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one

19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-

Estra-4,6-dien-3-one, 17-acetyl-17-hydroxy-6-methyl-, (17α)-

17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 17-HYDROXY-6-METHYL-19-NORPREGNA-4,6-DIENE-3,20-DIONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Nomegestrol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Nomegestrol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Nomegestrol

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