39012-20-9

39012-20-9 structure

Name: Picroside II
Chemical Name: Picroside II
CAS Number: 39012-20-9
Molecular Formula: C₂₃H₂₈O₁₃
Molecular Weight: 512.461
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-03-13 08:00:00
Modify Date: 2024-01-02 11:46:55
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways[1]. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury[2].

Name	Picroside II
Synonyms	AMPHICOSIDE Amphicoside II PicrosideII Vanilloyl catalpol Picroside-2 6'-VANILLOYL CATALPOL 2-(Hexopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxy-3-methoxybenzoate PICROSID II Benzoic acid, 4-hydroxy-3-methoxy-, 2-(hexopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester

Description	Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways[1]. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury[2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Huang Y, et al. Picroside II protects against sepsis via suppressing inflammation in mice. Am J Transl Res. 2016 Dec 15;8(12):5519-5531. eCollection 2016. [2]. Zhai L, et al. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS One. 2017 Apr 7;12(4):e0174414.

Density	1.7±0.1 g/cm3
Boiling Point	780.8±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₃
Molecular Weight	512.461
Flash Point	267.9±26.4 °C
Exact Mass	512.153015
PSA	197.13000
LogP	-2.50
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.681
Storage condition	2-8°C
Water Solubility	ethanol: soluble1mg/mL, clear, colorless

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport