Top Suppliers:I want be here




38183-03-8

38183-03-8 structure
38183-03-8 structure
  • Name: 7,8-Dihydroxyflavone
  • Chemical Name: 7,8-dihydroxyflavone
  • CAS Number: 38183-03-8
  • Molecular Formula: C15H10O4
  • Molecular Weight: 254.24
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-07-12 11:40:54
  • Modify Date: 2024-01-01 18:56:27
  • 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

Name 7,8-dihydroxyflavone
Synonyms 7,8-dihydroxy-2-phenylchromen-4-one
7,8-Dihydroxyflavone Hydrate
7,8-Dihydroxy-2-phenyl-4H-chromen-4-one
EINECS 253-812-4
7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
MFCD00006836
7,8-Dihydroxyflavone
4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-
Description 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
Related Catalog
Target

TrkB[1]

In Vitro 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].
In Vivo 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].
References

[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.

Density 1.4±0.1 g/cm3
Boiling Point 494.4±45.0 °C at 760 mmHg
Melting Point 243-246°C
Molecular Formula C15H10O4
Molecular Weight 254.24
Flash Point 193.5±22.2 °C
Exact Mass 254.057907
PSA 70.67000
LogP 2.51
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.699
Storage condition Store at +4°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3004000
CHEMICAL NAME :
4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-
CAS REGISTRY NUMBER :
38183-03-8
BEILSTEIN REFERENCE NO. :
0234350
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H10-O4
MOLECULAR WEIGHT :
254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
12500 ug/L
REFERENCE :
PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988
Hazard Codes Xn
Risk Phrases 22
Safety Phrases S24/25
RTECS DJ3004000
HS Code 2914400090
HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%