207306-50-1

207306-50-1 structure

Name: TB 21007
Chemical Name: 3-(2-hydroxyethylsulfanyl)-6,6-dimethyl-1-(1,3-thiazol-2-yl)-5,7-dihydro-2-benzothiophen-4-one
CAS Number: 207306-50-1
Molecular Formula: C₁₅H₁₇NO₂S₃
Molecular Weight: 339.49600
Create Date: 2017-02-04 00:19:12
Modify Date: 2023-04-04 21:35:42
TB-21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptor with a Ki of 1.6 nM. TB-21007 enhanced spatial memory in rats[1].

Name	3-(2-hydroxyethylsulfanyl)-6,6-dimethyl-1-(1,3-thiazol-2-yl)-5,7-dihydro-2-benzothiophen-4-one
Synonyms	Methyl 2,5-dihydroxycinnamate

Description	TB-21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptor with a Ki of 1.6 nM. TB-21007 enhanced spatial memory in rats[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Chambers MS, et al. Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. J Med Chem. 2003 May 22;46(11):2227-40.