43043-74-9

43043-74-9 structure

Name: Deoxyshikonin
Chemical Name: 5,8-dihydroxy-2-(4-methylpent-3-enyl)naphthalene-1,4-dione
CAS Number: 43043-74-9
Molecular Formula: C₁₆H₁₆O₄
Molecular Weight: 272.296
Catalog: Biochemical Plant extracts
Create Date: 2018-08-23 17:44:32
Modify Date: 2024-01-06 12:43:37
Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2].

Name	5,8-dihydroxy-2-(4-methylpent-3-enyl)naphthalene-1,4-dione
Synonyms	1'O-deoxyshikonin ARNEBIN-7 5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthoquinone deoxyalkannin 5,8-Dihydroxy-2-(4-methyl-3-pentenyl)-1,4-naphthalenedione 11-Deoxyalkannin 1,4-Naphthalenedione, 5,8-dihydroxy-2-(4-methyl-3-pentenyl)- 5,8-Dihydroxy-2-(4-methyl-pent-3-enyl)-1,4-naphthoquinone 1,4-Naphthalenedione, 5,8-dihydroxy-2-(4-methyl-3-penten-1-yl)- 5,8-Dihydroxy-2-(4-methyl-3-pentenyl)naphthoquinone deoxyshikonin 5,8-Dihydroxy-2-(4-methylpent-3-en-1-yl)-1,4-naphthoquinone

Description	Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Prangsaengtong O, et al. Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid Based Complement Alternat Med. 2013;2013:148297. [2]. Zhang S, et al. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479.

Safety Phrases	22-24/25
HS Code	2914690090

Precursor 0
DownStream 1
517-90-8

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%