Deoxyshikonin

Modify Date: 2024-01-06 12:43:37

Deoxyshikonin Structure
Deoxyshikonin structure
Common Name Deoxyshikonin
CAS Number 43043-74-9 Molecular Weight 272.296
Density 1.3±0.1 g/cm3 Boiling Point 503.7±50.0 °C at 760 mmHg
Molecular Formula C16H16O4 Melting Point 91ºC
MSDS N/A Flash Point 272.5±26.6 °C

 Use of Deoxyshikonin


Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2].

 Names

Name 5,8-dihydroxy-2-(4-methylpent-3-enyl)naphthalene-1,4-dione
Synonym More Synonyms

 Deoxyshikonin Biological Activity

Description Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2].
Related Catalog
References

[1]. Prangsaengtong O, et al. Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid Based Complement Alternat Med. 2013;2013:148297.

[2]. Zhang S, et al. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 503.7±50.0 °C at 760 mmHg
Melting Point 91ºC
Molecular Formula C16H16O4
Molecular Weight 272.296
Flash Point 272.5±26.6 °C
Exact Mass 272.104858
PSA 74.60000
LogP 4.72
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.611
Storage condition 2-8C

 Safety Information

Safety Phrases 22-24/25
HS Code 2914690090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2914690090
Summary 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

1'O-deoxyshikonin
ARNEBIN-7
5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthoquinone
deoxyalkannin
5,8-Dihydroxy-2-(4-methyl-3-pentenyl)-1,4-naphthalenedione
11-Deoxyalkannin
1,4-Naphthalenedione, 5,8-dihydroxy-2-(4-methyl-3-pentenyl)-
5,8-Dihydroxy-2-(4-methyl-pent-3-enyl)-1,4-naphthoquinone
1,4-Naphthalenedione, 5,8-dihydroxy-2-(4-methyl-3-penten-1-yl)-
5,8-Dihydroxy-2-(4-methyl-3-pentenyl)naphthoquinone
deoxyshikonin
5,8-Dihydroxy-2-(4-methylpent-3-en-1-yl)-1,4-naphthoquinone
Top Suppliers:I want be here



Get all suppliers and price by the below link:

Deoxyshikonin suppliers

Deoxyshikonin price

Hot Compounds More...
Dichloromethane
CAS#:75-09-2
Polyacrylic acid
CAS#:9003-01-4
sodium carbonate
CAS#:497-19-8
Silicon dioxide
CAS#:7631-86-9
Triethanolamine
CAS#:102-71-6
Demeton
CAS#:126-75-0
Water
CAS#:7732-18-5
4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9
Diclofenac sodium
CAS#:15307-79-6
Budesonide
CAS#:51372-29-3