94724-12-6

94724-12-6 structure

Name: Compound 48/80
Chemical Name: hydrogen, 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylam ino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]ph enyl]-N-methyl-ethanamine, dihydrochloride
CAS Number: 94724-12-6
Molecular Formula: C₃₂H₄₅N₃O₃
Molecular Weight: 519.72
Catalog: Research Areas Cancer
Create Date: 2018-12-25 20:10:31
Modify Date: 2024-01-02 10:52:12
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].

Name	hydrogen, 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylam ino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]ph enyl]-N-methyl-ethanamine, dihydrochloride
Synonyms	Benzenediazonium,2-carboxy-,chloride MFCD00077679 compound 48/80 benzenediazonium 2-carboxylate hydrochloride 2-Carboxy-benzoldiazonium,Chlorid o-carboxybenzenediazonium chloride 2-carboxy-benzenediazonium chloride benzeneethanamine-4-methoxy-3,5-bis{(2-methoxy-5-(2-methylaminoethyl)phenyl)methyl-N-methyl}

Description	Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Mast Cell Activator[1]
In Vitro	Compound 48/80 (poly-p-methoxyphenethylmethylamine), an agent commonly used to trigger degranulation of mast cells, at concentrations of 5-20 μg/ml suppresses the proliferation of L1210 and Friend leukemic cells in vitro, inducing the formation of giant cells, which are polykaryons[3].
References	[1]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. [2]. Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124. [3]. Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6.

848035-20-1

74-89-5

94724-12-6

Literature: IMPERIAL COLLEGE INNOVATIONS LTD Patent: WO2005/23744 A2, 2005 ; Location in patent: Page/Page column 16; 20-21 ;

702-23-8

94724-12-6

18217-00-0

94724-12-6

Precursor 4
848035-20-1 74-89-5 702-23-8 18217-00-0
DownStream 0