848035-21-2

848035-21-2 structure

Name: Compound 48/80 (hydrochloride)
Chemical Name: Compound 48/80 trihydrochloride
CAS Number: 848035-21-2
Molecular Formula: C₃₂H₄₈Cl₃N₃O₃
Molecular Weight: 629.10
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2020-06-01 08:39:04
Modify Date: 2025-08-24 13:14:34
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].

Name	Compound 48/80 trihydrochloride

Description	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Neurological Disease
In Vitro	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80[1].
In Vivo	Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter[3]. Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation[3]. Animal Model: 7-week-old Wistar male rats (fasted for 24 hours)[3] Dosage: 0.75 mg/kg Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
References	[1]. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. [2]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. [3]. Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80.

Molecular Formula	C₃₂H₄₈Cl₃N₃O₃
Molecular Weight	629.10

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