388627-21-2
388627-21-2 structure
- Name: GW297361
- Chemical Name: GW297361
- CAS Number: 388627-21-2
- Molecular Formula: C16H12N4O3S2
- Molecular Weight: 372.42
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2023-07-09 12:27:51
- Modify Date: 2024-01-23 10:27:10
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GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively[1].
| Name | GW297361 |
|---|
| Description | GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
yeast Cdk1:20 nM (IC50) yeast Pho85:400 nM (IC50) human CDK2:1.9 nM (IC50) human CDK9:10 nM (IC50) human CDK1:30 nM (IC50) human CDK4:300 nM (IC50) VEGFR2:120 nM (IC50) SRC:930 nM (IC50) |
| In Vitro | GW297361 (20 μM; 15 min) 部分抑制细胞内的 Cdk1[1]。 Western Blot Analysis[1] Cell Line: YRP1 cells Concentration: 20 μM Incubation Time: 20 μM Result: An intermediate level of the Orc6 was converted to the faster-migrating isoform (lower:upper = 2:1). |
| References |
| Molecular Formula | C16H12N4O3S2 |
|---|---|
| Molecular Weight | 372.42 |