684234-56-8

684234-56-8 structure

Name: PARP-1-IN-4
Chemical Name: WAY-323092
CAS Number: 684234-56-8
Molecular Formula: C₂₂H₁₅Cl₂N₃O₂
Molecular Weight: 424.28
Create Date: 2023-01-11 14:34:55
Modify Date: 2025-09-25 20:30:53
PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma[1].

Name	WAY-323092
Synonyms	2(1H)-Phthalazineacetamide, N,4-bis(4-chlorophenyl)-1-oxo- N-(4-Chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxo-2(1H)-phthalazinyl]acetamide

Description	PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	IC50: 302 μM (PARP-1)[1]
In Vitro	PARP-1-IN-4 对 PARP-1 具有抑制活性，IC50 值为 302 μM[1]。 PARP-1-IN-4 (0.1, 1 and 10 μM; 24h and 48h) 对 A549 细胞具有细胞毒性[1]。 PARP-1-IN-4 (1 μM; 24h) 显著增加 caspase-3 和 caspase-9 蛋白的表达水平[1]。 Cell Proliferation Assay[1] Cell Line: A549 cells Concentration: 0.1, 1 and 10 μM Incubation Time: 24h and 48h Result: Exhibited cytotoxicity activity against A549 cells.
References	[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456.