947699-46-9
947699-46-9 structure
- Name: ZIKV-IN-3
- Chemical Name: ZIKV-IN-3
- CAS Number: 947699-46-9
- Molecular Formula: C39H41NO4
- Molecular Weight: 587.75
- Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
- Create Date: 2022-10-09 14:09:07
- Modify Date: 2024-01-12 08:14:00
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ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV)[1].
| Name | ZIKV-IN-3 |
|---|
| Description | ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV)[1]. |
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| Related Catalog | |
| Target |
IC50: 18.34 μM (MTase)[1] |
| In Vitro | ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC50 value of 0.76 μM and has anti-ZIKV effect with EC50 values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively[1]. ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC50 value of 0.38 μM and inhibits ZIKV replication and infection[1]. ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells[1].Vero, Huh7 and A549 cells[1]. Cell Viability Assay[1] Cell Line: Vero, Huh7 and A549 cells Concentration: 0.08, 0.4, 2, 10, and 50 μM Incubation Time: 96 hours Result: Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC50>200 μM to all three cell lines. Western Blot Analysis[1] Cell Line: Vero cells Concentration: 0.08, 0.4, 2, 10, and 50 μM Incubation Time: 48 hours Result: Inhibited the expression of ZIKV E protein in a dose-dependent manner. |
| References |
| Molecular Formula | C39H41NO4 |
|---|---|
| Molecular Weight | 587.75 |