1314875-96-1

1314875-96-1 structure

Name: Trypanothione synthetase-IN-3
Chemical Name: Trypanothione synthetase-IN-3
CAS Number: 1314875-96-1
Molecular Formula: C₆₈H₅₄O₄₃
Molecular Weight: 1559.13
Catalog: Research Areas Infection
Create Date: 2022-10-23 10:59:46
Modify Date: 2024-02-03 14:13:19
Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (Ki: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum[1].

Name	Trypanothione synthetase-IN-3

Description	Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (Ki: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum[1].
Related Catalog	Research Areas >> Infection
Target	Trypanothione synthetase (TryS)[1]
In Vitro	Trypanothione synthetase-IN-3 (30 min) displays noncompetitive inhibitory behavior against Li TryS with IC50 values of 2 μM -5.6 μM (determined by various substrates)[1]. Trypanothione synthetase-IN-3 (24 h) inhibits proliferation of L. infantum axenic amastigotes with an EC50 value of 43.7 μM[1].
References	[1]. Mercedes Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022, 114675.

Molecular Formula	C₆₈H₅₄O₄₃
Molecular Weight	1559.13