651769-78-7

651769-78-7 structure

Name: Xanthine oxidoreductase-IN-3
Chemical Name: N-(4-chlorophenyl)-4-(2H-tetrazol-5-yl)benzamide
CAS Number: 651769-78-7
Molecular Formula: C₁₄H₁₀ClN₅O
Molecular Weight: 299.71500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Xanthine Oxidase
Create Date: 2017-06-18 04:02:25
Modify Date: 2024-04-06 09:35:50
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].

Name	N-(4-chlorophenyl)-4-(2H-tetrazol-5-yl)benzamide
Synonyms	Benzamide,N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)

Description	Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Target	IC50: 26.3 nM (xanthine oxidoreductase)[1]
In Vivo	Xanthine oxidoreductase-IN-3 (化合物 IIIa) (5 mg/kg; 口服给药) 在给药后 3 h 显示出降低急性高尿酸血症小鼠尿酸的作用[1]。 Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] Dosage: 5 mg/kg Administration: Suspended in 0.5% CMC-Na solution for intragastric administration Result: Showed a uric acid-lowering effect from 3 h after administration.
References	[1]. Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947.