2377724-93-9

2377724-93-9 structure

Name: c-Met-IN-13
Chemical Name: c-Met-IN-13
CAS Number: 2377724-93-9
Molecular Formula: C₃₀H₂₈F₂N₂O₆
Molecular Weight: 550.55
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
Create Date: 2022-09-10 12:04:25
Modify Date: 2024-04-06 10:27:59
c-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer[1].

Name	c-Met-IN-13

Description	c-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	c-Met:2.43 nM (IC50)
In Vitro	c-Met-IN-13 (compound 10m) shows cytotoxic activities with IC50s of 0.14, 0.20, 0.26 µM for H460, HT-29, MKN-45, respectively[1]. c-Met-IN-13 shows tyrosine kinases selectively with IC50s of 4.42, 6.15, 18.64, 295, 540, >10000, 2.43 nM for c-kit, Flt-3,Ron, VEGFR-2, Flt-4, EGFR, C-Met, respectively[1]. c-Met-IN-13 (0-300 µg/ml; 72 h) shows antiproliferative activity in a concentration and time dependent manner[1].
References	[1]. Nan X, et al. Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions. Eur J Med Chem. 2020 May 1;193:112241.

Molecular Formula	C₃₀H₂₈F₂N₂O₆
Molecular Weight	550.55