Shanghai Nianxing Industrial Co., Ltd
China
Product Name: c-Met-IN-1
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Purity: 98.0%
Stocking Period: 10 Day
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2084836-84-8

2084836-84-8 structure

2084836-84-8 structure

Name: c-met-IN-1
Chemical Name: c-met-IN-1
CAS Number: 2084836-84-8
Molecular Formula: C₃₅H₃₇FN₆O₅
Molecular Weight: 640.70
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
Create Date: 2019-08-04 14:26:58
Modify Date: 2025-08-26 22:39:47
c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].

Name	c-met-IN-1

Description	c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	IC50: 1.1 nM (c-Met)[1]
In Vitro	c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1].
References	[1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896.

Molecular Formula	C₃₅H₃₇FN₆O₅
Molecular Weight	640.70

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