1446324-05-5

1446324-05-5 structure

1446324-05-5 structure

Name: c-Met-IN-11
Chemical Name: c-Met-IN-11
CAS Number: 1446324-05-5
Molecular Formula: C₃₀H₂₀F₂N₄O₃
Molecular Weight: 522.50
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
Create Date: 2022-06-28 09:34:06
Modify Date: 2024-04-08 20:05:20
c-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1].

Name	c-Met-IN-11

Description	c-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	c-Met:41.4 nM (IC50) VEGFR-2:71.1 nM (IC50)
References	[1]. Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555.

Molecular Formula	C₃₀H₂₀F₂N₄O₃
Molecular Weight	522.50