59453-24-6

59453-24-6 structure

Name: Bromperidol hydrochloride
Chemical Name: Bromperidol hydrochloride
CAS Number: 59453-24-6
Molecular Formula: C₂₁H₂₄BrClFNO₂
Molecular Weight: 456.78
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-09-07 19:16:29
Modify Date: 2024-01-10 18:27:45
Bromperidol hydrochloride (R-11333 hydrochloride) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol hydrochloride can kill mycobacteria in a synergistic manner with Spectinomycin[1][2].

Name	Bromperidol hydrochloride

Description	Bromperidol hydrochloride (R-11333 hydrochloride) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol hydrochloride can kill mycobacteria in a synergistic manner with Spectinomycin[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
Target	D2 Receptor
In Vivo	Bromperidol hydrochloride antagonises stereotyped behaviour and agitation induced by apomorphine or amphetamine, and inhibits conditioned reactions and learned intracranial self-stimulation in rats[1]. Bromperidol hydrochloride antagonises apomorphine-induced emesis and inhibits the conditioned avoidance response in dogs[1].
References	[1]. Benfield P, et al. Bromperidol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in psychoses. Drugs. 1988 Jun;35(6):670-84. [2]. Ramón-García S, et al. Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrob Agents Chemother. 2011 Aug;55(8):3861-9.

Molecular Formula	C₂₁H₂₄BrClFNO₂
Molecular Weight	456.78