2488706-33-6
2488706-33-6 structure
- Name: PAK4-IN-2
- Chemical Name: PAK4-IN-2
- CAS Number: 2488706-33-6
- Molecular Formula: C18H21ClN6
- Molecular Weight: 356.85
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-07-01 20:07:23
- Modify Date: 2024-01-10 18:39:33
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PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer[1].
| Name | PAK4-IN-2 |
|---|
| Description | PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer[1]. |
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| Related Catalog | |
| Target |
PAK3:2.7 nM (IC50) |
| In Vitro | PAK4-IN-2 (compound 5n) (0-10 μM; 72 hours) exhibits cell growth inhibition potency in hematoma tumor MV4-11 and solid tumor cell line MDA-MB-231, shows less sensitivity in normal human renal epithelial cell 239 T cell[1]. PAK4-IN-2 (5-50 nM; 48 hours) causes a majority of cells in G0/G1 phase with decreasing S-phase populations[1]. PAK4-IN-2 (10-250 nM; 48 hours) induces apoptosis in a dose-dependent manner[1]. PAK4-IN-2 (50-800 nM; 24 hours) markedly reduces the expression levels of p-PAK4(Ser474) in concentration dependently[1]. Cell Proliferation Assay Cell Line: MV4-11, MDA-MB-231 and 293T[1] Concentration: 0-10 μM Incubation Time: 72 hours Result: Exhibited significant cell growth inhibition potency in hematoma tumor MV4-11 (IC50 = 7.8 ± 2.8 nM), and moderate potent anti-proliferative effect in solid tumor cell line MDA-MB-231 (IC50 = 825 ± 106 nM), less sensitivity in normal human renal epithelial cell 239 T cell (IC50 > 10000 nM). Cell Cycle Analysis Cell Line: MV4-11[1] Concentration: 5, 10 and 50 nM Incubation Time: 48 hours Result: Caused a majority of cells in G0/G1 phase with decreasing S-phase populations. Apoptosis Analysis Cell Line: MV4-11[1] Concentration: 10, 50 and 250 nM Incubation Time: 48 hours Result: Induced apoptosis in a dose-dependent manner. Western Blot Analysis Cell Line: MV4-11[1] Concentration: 50, 200 and 800 nM Incubation Time: 24 hours Result: Markedly reduced the expression levels of p-PAK4(Ser474) in concentration dependently. |
| References |
| Molecular Formula | C18H21ClN6 |
|---|---|
| Molecular Weight | 356.85 |