2719736-43-1

2719736-43-1 structure

Name: DNA-PK-IN-5
Chemical Name: DNA-PK-IN-5
CAS Number: 2719736-43-1
Molecular Formula: C₂₁H₂₂N₈O₂
Molecular Weight: 418.45
Create Date: 2022-05-19 18:45:36
Modify Date: 2024-01-05 08:02:33
DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of drug resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2)[1].

Name	DNA-PK-IN-5

Description	DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of drug resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
References	[1]. Xinhai Chen, et al. Aminopyrimidine compounds and their derivatives as dna-pk inhibitors. Patent WO2021204111A1.

Molecular Formula	C₂₁H₂₂N₈O₂
Molecular Weight	418.45