1643462-93-4
1643462-93-4 structure
- Name: PW0464
- Chemical Name: PW0464
- CAS Number: 1643462-93-4
- Molecular Formula: C19H17F2N3O4
- Molecular Weight: 389.35
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2021-09-06 08:33:02
- Modify Date: 2024-01-08 12:25:45
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PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1].
| Name | PW0464 |
|---|
| Description | PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment[1]. PW0464 (compound 24), the non-catechol agonist, forms bonds with S1985.42 and S2025.46 via its fluorine atom[2]. |
| References |
| Molecular Formula | C19H17F2N3O4 |
|---|---|
| Molecular Weight | 389.35 |