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38090-53-8

38090-53-8 structure
38090-53-8 structure
  • Name: TACA
  • Chemical Name: trans-4-Aminocrotonicacid
  • CAS Number: 38090-53-8
  • Molecular Formula: C4H7NO2
  • Molecular Weight: 101.10400
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2018-09-13 18:59:24
  • Modify Date: 2025-08-23 01:21:34
  • TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons[1][2][3].
Name trans-4-Aminocrotonicacid
Synonyms MFCD00673818
4-Amino-trans-crotonsaeure
4-amino-trans-crotonic acid
trans-4-Aminocrotonic acid,TACA
4-amino-2-butenoic acid
trans-4-aminocrotonic acid
Description TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons[1][2][3].
Related Catalog
Target

KD: 0.6 μM (GABAC)[1].

In Vivo TACA is a potent competitive inhibitor of GABA uptake in rat brain slices and thus is possibly a substrate for the GABA uptake system[3].
References

[1]. Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122(8):1551-1560.

[2]. Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82(3):1489-1496.

[3]. Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24(1):157-160.
Density 1.169 g/cm3
Boiling Point 300.4ºC at 760 mmHg
Melting Point >158°C (lit.)
Molecular Formula C4H7NO2
Molecular Weight 101.10400
Flash Point 135.5ºC
Exact Mass 101.04800
PSA 63.32000
LogP 0.28620
Safety Phrases S22-S24/25
924-49-2 structure

924-49-2

~%

38090-53-8 structure

38090-53-8

Literature: Musashi Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954 , vol. 297, p. 71 Full Text View citing articles Show Details Johnston et al. J.Neurochem., 1975 , vol. 24, p. 157
100814-78-6 structure

100814-78-6

~%

38090-53-8 structure

38090-53-8

Literature: Merck and Co., Inc. Patent: US4579851 A1, 1986 ; US 4579851 A
13991-36-1 structure

13991-36-1

~%

38090-53-8 structure

38090-53-8

Literature: Liu, Siming; Hanzlik, Robert P. Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1067 - 1075
75707-06-1 structure

75707-06-1

~53%

38090-53-8 structure

38090-53-8

Literature: Allan; Johnston; Twitchin Australian Journal of Chemistry, 1980 , vol. 33, # 5 p. 1115 - 1122
16011-10-2 structure

16011-10-2

~%

38090-53-8 structure

38090-53-8

Literature: Balenovic et al. Journal of Organic Chemistry, 1954 , vol. 19, p. 1589,1591
107-93-7 structure

107-93-7

~%

38090-53-8 structure

38090-53-8

Literature: Allan,R.D.; Twitchin,B. Australian Journal of Chemistry, 1978 , vol. 31, p. 2283 - 2289
10479-85-3 structure

10479-85-3

7664-41-7 structure

7664-41-7

~%

38090-53-8 structure

38090-53-8

Literature: Rambaud Bulletin de la Societe Chimique de France, 1936 , vol. <5>3, p. 139
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