130465-39-3
130465-39-3 structure
- Name: A-68930 hydrochloride
- Chemical Name: A-68930 hydrochloride
- CAS Number: 130465-39-3
- Molecular Formula: C16H18ClNO3
- Molecular Weight: 307.77200
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2019-01-02 16:15:37
- Modify Date: 2025-08-24 21:02:40
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A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].
| Name | A-68930 hydrochloride |
|---|---|
| Synonyms |
cis-1-(Aminomethyl)-3-phenylisochroman-5,6-diol hydrochloride
(1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol,hydrochloride |
| Description | A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1]. |
|---|---|
| Related Catalog | |
| Target |
D1 Receptor |
| In Vitro | A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1]. A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1]. A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1]. Western Blot Analysis[1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased. |
| References |
| Melting Point | 250ºC |
|---|---|
| Molecular Formula | C16H18ClNO3 |
| Molecular Weight | 307.77200 |
| Exact Mass | 307.09800 |
| PSA | 75.71000 |
| LogP | 3.91390 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2932999099 |
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130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
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130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
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130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
|
~%
130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
|
~%
130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
|
~%
130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
|
~%
130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
|
~%
130465-39-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 11 p. 2948 - 2950 |
| Precursor 7 | |
|---|---|
| DownStream 0 | |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |