Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,5-Isoquinolinediol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

5154-02-9

5154-02-9 structure

5154-02-9 structure

Name: 1,5-Isoquinolinediol
Chemical Name: isoquinoline-1,5-diol
CAS Number: 5154-02-9
Molecular Formula: C₉H₇NO₂
Molecular Weight: 161.157
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2018-09-12 21:34:35
Modify Date: 2025-08-25 13:02:36
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].

Name	isoquinoline-1,5-diol
Synonyms	isoquinoline-1,5-diol 5-Hydroxyisocarbostyril 5-Hydroxy-1(2H)-isoquinolinone 5-Hydroxyisoquinoline-1(2H)-one 1(2H)-Isoquinolinone, 5-hydroxy- 1,5-Dihydroxyisoquinoline 5-Hydroxy-1(2H)-isoquinolinone DiQ 5-hydroxy-2H-isoquinolin-1-one MFCD00006900 5-Hydroxyisoquinolin-1(2H)-one 1,5-Isoquinolinediol

Description	1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP:0.18-0.37 μM (IC50)
In Vitro	1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1]. 1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2].
References	[1]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.

Density	1.4±0.1 g/cm3
Boiling Point	501.1±30.0 °C at 760 mmHg
Melting Point	270-275 °C
Molecular Formula	C₉H₇NO₂
Molecular Weight	161.157
Flash Point	256.8±24.6 °C
Exact Mass	161.047684
PSA	53.35000
LogP	-0.17
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.743
Storage condition	2-8°C
Water Solubility	DMSO: >36 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933499090

Precursor 0
DownStream 3
56469-02-4 762236-09-9 129075-87-2

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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