5154-02-9
5154-02-9 structure
- Name: 1,5-Isoquinolinediol
- Chemical Name: isoquinoline-1,5-diol
- CAS Number: 5154-02-9
- Molecular Formula: C9H7NO2
- Molecular Weight: 161.157
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2018-09-12 21:34:35
- Modify Date: 2024-01-02 20:49:07
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1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].
| Name | isoquinoline-1,5-diol |
|---|---|
| Synonyms |
isoquinoline-1,5-diol
5-Hydroxyisocarbostyril 5-Hydroxy-1(2H)-isoquinolinone 5-Hydroxyisoquinoline-1(2H)-one 1(2H)-Isoquinolinone, 5-hydroxy- 1,5-Dihydroxyisoquinoline 5-Hydroxy-1(2H)-isoquinolinone DiQ 5-hydroxy-2H-isoquinolin-1-one MFCD00006900 5-Hydroxyisoquinolin-1(2H)-one 1,5-Isoquinolinediol |
| Description | 1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PARP:0.18-0.37 μM (IC50) |
| In Vitro | 1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1]. 1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 501.1±30.0 °C at 760 mmHg |
| Melting Point | 270-275 °C |
| Molecular Formula | C9H7NO2 |
| Molecular Weight | 161.157 |
| Flash Point | 256.8±24.6 °C |
| Exact Mass | 161.047684 |
| PSA | 53.35000 |
| LogP | -0.17 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.743 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: >36 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933499090 |
| Precursor 0 | |
|---|---|
| DownStream 3 | |
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |