95041-90-0

95041-90-0 structure

Name: Erianin
Chemical Name: 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol
CAS Number: 95041-90-0
Molecular Formula: C₁₈H₂₂O₅
Molecular Weight: 318.364
Catalog: Biochemical Plant extracts
Create Date: 2018-08-04 11:50:47
Modify Date: 2024-01-02 09:58:28
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

Name	2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol
Synonyms	Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]- Dihydrocombretatastin A-4 Erianin 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-ethyl]-phenol 5-(3,4,5-trimethoxyphenethyl)-2-methoxyphenol 2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol (E)-2-methoxy-5-(3,4,5-trimethoxyphenylethyl)phenol 3-hydroxy-3',4',4,5'-tetramethoxybibenzyl 2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]benzolol

Description	Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Neurological Disease Natural Products >> Others
In Vitro	Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%[1]. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose‑ and time‑dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase‑3, but decreases levels of Bcl‑2 and phosphorylated‑ERK1/2[2].
References	[1]. Su C, et al. Erianin inhibits indoleamine 2, 3-dioxygenase -induced tumor angiogenesis. Biomed Pharmacother. 2017 Apr;88:521-528. [2]. Li M, et al. Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway. Oncol Lett. 2018 Oct;16(4):5006-5012.