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520-34-3

520-34-3 structure
520-34-3 structure
  • Name: Diosmetin
  • Chemical Name: diosmetin
  • CAS Number: 520-34-3
  • Molecular Formula: C16H12O6
  • Molecular Weight: 300.263
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-02-19 08:00:00
  • Modify Date: 2024-01-02 19:05:04
  • Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
Name diosmetin
Synonyms Vitamin P
3',5,7-dihydroxy-4'-methoxyflavone
Cyanidenon-4'-methyl Ether 1479
3,3',5,7-tetrahydroxy-4'-methoxyflavone
4'-Methylluteolin
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
5,7,3'-Trihydroxy-4'-methoxyflavone
MFCD00017425
3',5,7-trihydroxy-4'-methoxy-2-phenylchromone
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
Luteolin 4'-methyl ether
3',5,7-TRIHYDROXY-4'METHOXYFLAVONE
Diosmetin
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-
Luteolin-4'-methyl Ether
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
EINECS 208-291-8
Salinigricoflavonol
Description Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
Related Catalog
Target

IC50: 40 μM (Others, HepG2 cell)[1]

In Vitro Diosmetin inhibits cell proliferation in HepG2 cells in a concentration-dependent manner. Untreated HepG2 cells grow well and are observed to have with normal skeletons, whereas cells treated with diosmetin are distorted and a number of them become round and floating[1].
In Vivo Pretreatment with diosmetin significantly reduces serum levels of amylase and lipase; the histological injury; the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6; myeloperoxidase (MPO) activity, trypsinogen activation peptide (TAP) level, the expression of inducible nitric oxide synthase (iNOS); and the nuclear factor (NF)-κB activation in cerulein-induced acute pancreatitis[2].
Cell Assay Diosmetin is dissolved in DMSO which is maintained at a constant concentration in control samples (2%). HepG2 cells are maintained in a humidified atmosphere of 5% CO2 at 37°C, and cultured in RPMI-1640 medium supplemented with 10% (v/v) fetal bovine serum, 100 U/mL penicillin and 100 U/mL streptomycin. HepG2 cell density is adjusted to 2×104 cells/100 μL, and the cells are seeded into 96-well plates and placed in an incubator overnight (37°C in 5% CO2) to allow for attachment and recovery. MTT analyses are performed. Briefly, cells are pretreated with 5, 10, 15 and 20 μg/mL diosmetin for 24 h. A total of 20 μL MTT solution (5 mg/mL in PBS) solution is transferred to each well to yield a final 120 μL/well and to separate wells a total of 10 μL CCK8 (5 mg/mL in PBS) is transferred. The plates are incubated for 4 h at 37°C in 5% CO2 and the absorbance is recorded at wavelengths of 595 nm and 450 nm, respectively. The half maximal inhibitory concentration (IC50) of diosmetin is calculated[1].
Animal Admin Experimental acute pancreatitis is induced in mice by seven intraperitoneal injection of cerulein (50 μg/kg) at hourly intervals. Diosmetin (100 mg/kg) or vehicle is pretreated 2 h before the first cerulein injection. After 6 h, 9 h, 12 h of the first cerulein injection, the severity of acute pancreatitis is evaluated biochemically and morphologically[2].
References

[1]. Liu B, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016 Jul;14(1):159-64.

[2]. Yu G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42.
Density 1.5±0.1 g/cm3
Boiling Point 576.7±50.0 °C at 760 mmHg
Melting Point 256-258ºC
Molecular Formula C16H12O6
Molecular Weight 300.263
Flash Point 220.3±23.6 °C
Exact Mass 300.063385
PSA 100.13000
LogP 3.10
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.697
Storage condition -20?C Freezer
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi: Irritant;
Risk Phrases 22
RIDADR NONH for all modes of transport
HS Code 2942000000
HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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