158921-85-8

158921-85-8 structure

Name: APC 366
Chemical Name: APC 366
CAS Number: 158921-85-8
Molecular Formula: C₂₂H₂₈N₆O₄
Molecular Weight: 440.496
Create Date: 2021-05-08 11:49:56
Modify Date: 2024-01-23 17:19:56
APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].

Name	APC 366
Synonyms	L-Prolinamide, N5-(diaminomethylene)-N2-[(1-hydroxy-2-naphthalenyl)carbonyl]-L-ornithyl- N5-(Diaminomethylene)-N2-(1-hydroxy-2-naphthoyl)-L-ornithyl-L-prolinamide N2-[(1-hydroxynaphthalen-2-yl)carbonyl]-L-arginyl-L-prolinamide

Description	APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Inflammation/Immunology
References	[1]. Barrios VE, et al. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998;63(26):2295-2303. [2]. Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol. 2001;107(6):1039-1045.