1909226-00-1
1909226-00-1 structure
- Name: BDA-366
- Chemical Name: BDA-366
- CAS Number: 1909226-00-1
- Molecular Formula: C24H29N3O4
- Molecular Weight: 423.50
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2018-07-18 00:33:00
- Modify Date: 2024-01-08 08:37:29
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BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1].
| Name | BDA-366 |
|---|---|
| Synonyms |
9,10-Anthracenedione, 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiranylmethyl]amino]-
BDA-366 1-{[(2S)-3-(Diethylamino)-2-hydroxypropyl]amino}-4-{[(2S)-2-oxiranylmethyl]amino}-9,10-anthraquinone |
| Description | BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1]. |
|---|---|
| Related Catalog | |
| Target |
Bcl-2:3.3 nM (Ki) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 669.4±55.0 °C at 760 mmHg |
| Molecular Formula | C24H29N3O4 |
| Molecular Weight | 423.50 |
| Flash Point | 358.6±31.5 °C |
| Exact Mass | 423.215820 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.665 |
| Storage condition | -20℃ |