1431628-22-6
1431628-22-6 structure
- Name: (S)-UFR2709
- Chemical Name: (S)-UFR2709
- CAS Number: 1431628-22-6
- Molecular Formula: C13H17NO2
- Molecular Weight: 219.28
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2020-11-28 14:12:08
- Modify Date: 2024-01-05 16:06:23
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(S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].
| Name | (S)-UFR2709 |
|---|
| Description | (S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2]. |
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| Related Catalog | |
| In Vitro | Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, which is a molecular target for the treatment of alcohol abuse and dependence[1]. |
| In Vivo | (S)-UFR2709 (50-100 μg/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 μg/ml[2]. (S)-UFR2709 (50-100 μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit, but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish[2]. (S)-UFR2709 (intraperitoneal injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption. (S)-UFR2709 does not affect the weight or locomotor activity of the rats[1]. Animal Model: High-alcohol-drinking UChB rats[1] Dosage: 10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg Administration: Intraperitoneal injection; 1-10 mg/kg; daily; 17 days Result: Did not affect the weight or locomotor activity and reduced ethanol consumption and preference. |
| References |
| Molecular Formula | C13H17NO2 |
|---|---|
| Molecular Weight | 219.28 |