2267282-19-7
2267282-19-7 structure
- Name: (S,R,S)-AHPC-C5-COOH
- Chemical Name: (S,R,S)-AHPC-C5-COOH
- CAS Number: 2267282-19-7
- Molecular Formula: C29H42N4O5S
- Molecular Weight: 558.73
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2020-06-01 16:38:59
- Modify Date: 2024-04-04 00:05:08
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(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].
| Name | (S,R,S)-AHPC-C5-COOH |
|---|
| Description | (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1]. |
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| Related Catalog | |
| Target |
VHL |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.The von Hippel–Lindau tumor suppressor protein is the substrate-binding subunit of the VHL E3 ubiquitin ligase, it targets hydroxylated α subunit of HIFs for ubiquitination and subsequent proteasomal degradation. |
| References |
| Molecular Formula | C29H42N4O5S |
|---|---|
| Molecular Weight | 558.73 |
| Hazard Codes | Xi |
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