1467740-78-8
1467740-78-8 structure
- Name: Galidesivir triphosphate
- Chemical Name: Galidesivir triphosphate
- CAS Number: 1467740-78-8
- Molecular Formula: C11H18N5O12P3
- Molecular Weight: 505.21
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-06-01 08:51:48
- Modify Date: 2024-01-10 14:02:28
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Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola[1][2].
| Name | Galidesivir triphosphate |
|---|
| Description | Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola[1][2]. |
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| Related Catalog | |
| In Vitro | In virus-infected cells, Galidesivir is converted to the triphosphate, is incorporated into the viral transcript, and functions as an atypical chain-terminator for RNA-dependent RNA polymerases. Galidesivir is converted to the mono-, di-, and triphosphates in virus-infected human Huh-7 cells[1]. Galidesivir triphosphate (Immucillin-A triphosphate) (1-60 μM) inhibits hepatitis C virus (HCV) RNA polymerase transcriptional activity in a cell-free, isolated enzyme transcription assay.The triphosphate is a substrate for viral RNA-dependent RNA polymerase. Its incorporation permits the addition of a few additional encoded bases at which point the Galidesivir-modified RNA cannot be elongated[2]. |
| In Vivo | In vivo conversion of Galidesivir to its TP (Galidesivir triphosphate) nucleotide is particularly efficient[3] |
| References |
[1]. Evans GB, et al. Immucillins in Infectious Diseases. ACS Infect Dis. 2018 Feb 9;4(2):107-117. |
| Molecular Formula | C11H18N5O12P3 |
|---|---|
| Molecular Weight | 505.21 |