Galidesivir triphosphate
Modify Date: 2025-08-25 17:48:39
Galidesivir triphosphate structure
|
Common Name | Galidesivir triphosphate | ||
|---|---|---|---|---|
| CAS Number | 1467740-78-8 | Molecular Weight | 505.21 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H18N5O12P3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Galidesivir triphosphateGalidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola[1][2]. |
| Name | Galidesivir triphosphate |
|---|
| Description | Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | In virus-infected cells, Galidesivir is converted to the triphosphate, is incorporated into the viral transcript, and functions as an atypical chain-terminator for RNA-dependent RNA polymerases. Galidesivir is converted to the mono-, di-, and triphosphates in virus-infected human Huh-7 cells[1]. Galidesivir triphosphate (Immucillin-A triphosphate) (1-60 μM) inhibits hepatitis C virus (HCV) RNA polymerase transcriptional activity in a cell-free, isolated enzyme transcription assay.The triphosphate is a substrate for viral RNA-dependent RNA polymerase. Its incorporation permits the addition of a few additional encoded bases at which point the Galidesivir-modified RNA cannot be elongated[2]. |
| In Vivo | In vivo conversion of Galidesivir to its TP (Galidesivir triphosphate) nucleotide is particularly efficient[3] |
| References |
[1]. Evans GB, et al. Immucillins in Infectious Diseases. ACS Infect Dis. 2018 Feb 9;4(2):107-117. |
| Molecular Formula | C11H18N5O12P3 |
|---|---|
| Molecular Weight | 505.21 |
| InChIKey | NMSMIMMTMMGSHI-KUBHLMPHSA-N |
| SMILES | Nc1ncnc2c(C3NC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O)c[nH]c12 |