1638178-87-6
1638178-87-6 structure
- Name: ONC206
- Chemical Name: ONC206
- CAS Number: 1638178-87-6
- Molecular Formula: C23H22F2N4O
- Molecular Weight: 408.44
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2020-01-23 11:37:51
- Modify Date: 2024-01-08 17:23:51
-
ONC206 is an analogue of TRAIL inducer ONC201[1]. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity[2].
| Name | ONC206 |
|---|
| Description | ONC206 is an analogue of TRAIL inducer ONC201[1]. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity[2]. |
|---|---|
| Related Catalog | |
| Target |
DRD2/3/4[2] |
| In Vitro | ONC206 selectively antagonizes the D2-like (DRD2/3/4), but not the D1-like (DRD 1/5), subfamily of dopamine receptors[2]. ONC206 significantly inhibits tumor cell migration and invasion in vitro[1]. ONC206 (0.05 μM; Over 48 hours) inhibits migration of ONC201- and TRAIL-resistant HCT116 Bax−/− cells without inducing cell death or inhibiting cell proliferation[1]. ONC206 engages the ISR and TRAIL pathway leading to tumor growth arrest and cell death[1]. ONC206 does not induce cell cycle arrest in a colorectal cell line with acquired ONC201-resistance[1]. Cell Proliferation Assay[1] Cell Line: HCT116 cells Concentration: 0.05 μM Incubation Time: Over 48 hours Result: Inhibited migration of ONC201- and TRAIL-resistant HCT116 Bax−/− cells. |
| In Vivo | ONC206 (100 mg/kg;p.o.; every 10 days) causes significant tumor growth inhibition[2]. |
| References |
| Molecular Formula | C23H22F2N4O |
|---|---|
| Molecular Weight | 408.44 |
| Hazard Codes | C |
|---|