790663-33-1
790663-33-1 structure
- Name: PBD-150
- Chemical Name: PBD-150
- CAS Number: 790663-33-1
- Molecular Formula: C15H20N4O2S
- Molecular Weight: 320.411
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-01-20 16:34:56
- Modify Date: 2025-08-26 20:17:23
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A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM; significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.
| Name | PBD-150 |
|---|
| Description | A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM; significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas. |
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| Related Catalog | |
| In Vivo | PBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals[3]. |
| References |
| Molecular Formula | C15H20N4O2S |
|---|---|
| Molecular Weight | 320.411 |