DC Chemicals Limited
China
Product Name: PBD-150
Price: $550.0/100mg $950.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

790663-33-1

790663-33-1 structure

790663-33-1 structure

Name: PBD-150
Chemical Name: PBD-150
CAS Number: 790663-33-1
Molecular Formula: C₁₅H₂₀N₄O₂S
Molecular Weight: 320.411
Catalog: Research Areas Neurological Disease
Create Date: 2020-01-20 16:34:56
Modify Date: 2024-01-09 08:23:39
A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM; significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.

Name	PBD-150

Description	A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM; significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.
Related Catalog	Research Areas >> Neurological Disease
In Vivo	PBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals[3].
References	[1]. Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77. [2]. DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92. [3]. Huang KF, et al. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem. 2011 Apr 8;286(14):12439-49.

Molecular Formula	C₁₅H₂₀N₄O₂S
Molecular Weight	320.411