1661020-92-3

1661020-92-3 structure

Name: MW-150 dihydrochloride dihydrate
Chemical Name: MW-150 dihydrochloride dihydrate
CAS Number: 1661020-92-3
Molecular Formula: C₂₄H₂₉Cl₂N₅O₂
Molecular Weight: 490.43
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2019-06-01 19:01:56
Modify Date: 2024-01-09 20:17:10
MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective inhibitor of p38αMAPK isoform with a ki of 101 nM[1].

Name	MW-150 dihydrochloride dihydrate

Description	MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective inhibitor of p38αMAPK isoform with a ki of 101 nM[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Neurological Disease
Target	p38α:101 nM (Ki)
In Vitro	MW-150 dihydrochloride dihydrate inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1]. MW-150 dihydrochloride dihydrate blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].
In Vivo	MW-150 dihydrochloride dihydrate (2.5 mg/kg; oral daily for 3−4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1]. MW-150 dihydrochloride dihydrate (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].
References	[1]. Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.