313669-88-4
313669-88-4 structure
- Name: BMS 986122
- Chemical Name: BMS-986122
- CAS Number: 313669-88-4
- Molecular Formula: C16H15BrClNO3S2
- Molecular Weight: 448.782
- Create Date: 2020-01-11 10:32:02
- Modify Date: 2025-08-25 17:57:07
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BMS-986122 is a potent positive allosteric modulator of μ-opioid receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells.
| Name | BMS-986122 |
|---|---|
| Synonyms |
Thiazolidine, 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-1,3-thiazolidine BMS-986122 |
| Description | BMS-986122 is a potent positive allosteric modulator of μ-opioid receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells. |
|---|---|
| References | References 1. Burford NT, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. 2. Livingston KE, et al. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18369-74. 3. Livingston KE, et al. Mol Pharmacol. 2018 Feb;93(2):157-167. View Related Products by Target Opioid Receptor |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.2±60.0 °C at 760 mmHg |
| Molecular Formula | C16H15BrClNO3S2 |
| Molecular Weight | 448.782 |
| Flash Point | 296.8±32.9 °C |
| Exact Mass | 446.936523 |
| LogP | 5.14 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.648 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |