884600-68-4

884600-68-4 structure

Name: GSM-1
Chemical Name: GSM-1
CAS Number: 884600-68-4
Molecular Formula: C₂₆H₃₁ClF₃NO₂
Molecular Weight: 481.978
Catalog: Research Areas Neurological Disease
Create Date: 2020-01-13 03:45:58
Modify Date: 2025-08-25 13:01:12
GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay; does not affect total Aβ and its C-terminal counterpart product, APP intracellular domain (AICD), selectively reduced the Aβ42 generation accompanied by an increase in Aβ38 in in-vitro assay; decreases the ratio of Aβ42 to Aβ40 to 60% in plasma and the ratio of Aβ42 to total Aβ to 65% in cerebrospinal fluid from baseline to postdosing in monkeys (30 mg/kg)

Name	GSM-1
Synonyms	{(2S,4R)-1-[(1R)-1-(4-Chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetic acid RY5QK2J15V GSM-1 4-Piperidineacetic acid, 1-[(1R)-1-(4-chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]-, (2S,4R)-

Description	GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay; does not affect total Aβ and its C-terminal counterpart product, APP intracellular domain (AICD), selectively reduced the Aβ42 generation accompanied by an increase in Aβ38 in in-vitro assay; decreases the ratio of Aβ42 to Aβ40 to 60% in plasma and the ratio of Aβ42 to total Aβ to 65% in cerebrospinal fluid from baseline to postdosing in monkeys (30 mg/kg)
References	References 1. Page RM, et al. J Biol Chem. 2010 Jun 4;285(23):17798-810. 2. Kretner B, et al. J Biol Chem. 2011 Apr 29;286(17):15240-51. 3. Ohki Y, et al. EMBO J. 2011 Oct 14;30(23):4815-24. 4. Ling IF, et al. Alzheimers Res Ther. 2015 Aug 5;7(1):55. View Related Products by Target γ-secretase