GSM-1
Modify Date: 2025-08-25 13:01:12
GSM-1 structure
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Common Name | GSM-1 | ||
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| CAS Number | 884600-68-4 | Molecular Weight | 481.978 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 547.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H31ClF3NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 285.0±30.1 °C | |
Use of GSM-1GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay; does not affect total Aβ and its C-terminal counterpart product, APP intracellular domain (AICD), selectively reduced the Aβ42 generation accompanied by an increase in Aβ38 in in-vitro assay; decreases the ratio of Aβ42 to Aβ40 to 60% in plasma and the ratio of Aβ42 to total Aβ to 65% in cerebrospinal fluid from baseline to postdosing in monkeys (30 mg/kg) |
| Name | GSM-1 |
|---|---|
| Synonym | More Synonyms |
| Description | GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay; does not affect total Aβ and its C-terminal counterpart product, APP intracellular domain (AICD), selectively reduced the Aβ42 generation accompanied by an increase in Aβ38 in in-vitro assay; decreases the ratio of Aβ42 to Aβ40 to 60% in plasma and the ratio of Aβ42 to total Aβ to 65% in cerebrospinal fluid from baseline to postdosing in monkeys (30 mg/kg) |
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| References | References 1. Page RM, et al. J Biol Chem. 2010 Jun 4;285(23):17798-810. 2. Kretner B, et al. J Biol Chem. 2011 Apr 29;286(17):15240-51. 3. Ohki Y, et al. EMBO J. 2011 Oct 14;30(23):4815-24. 4. Ling IF, et al. Alzheimers Res Ther. 2015 Aug 5;7(1):55. View Related Products by Target γ-secretase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 547.7±50.0 °C at 760 mmHg |
| Molecular Formula | C26H31ClF3NO2 |
| Molecular Weight | 481.978 |
| Flash Point | 285.0±30.1 °C |
| Exact Mass | 481.199554 |
| LogP | 6.96 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.531 |
| {(2S,4R)-1-[(1R)-1-(4-Chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetic acid |
| RY5QK2J15V |
| GSM-1 |
| 4-Piperidineacetic acid, 1-[(1R)-1-(4-chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]-, (2S,4R)- |