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1820934-93-7

1820934-93-7 structure
1820934-93-7 structure
  • Name: GlyT1 inhibitor 46
  • Chemical Name: GlyT1 Inhibitor 1
  • CAS Number: 1820934-93-7
  • Molecular Formula: C22H21N5O2
  • Molecular Weight: 387.43
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
  • Create Date: 2019-03-03 21:30:07
  • Modify Date: 2024-01-10 19:38:07
  • GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].

Name GlyT1 Inhibitor 1
Description GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].
Related Catalog
Target

rGlyT1:38 nM (IC50)

In Vivo GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg[1].
References

[1]. Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61(14):6018-6033.

Molecular Formula C22H21N5O2
Molecular Weight 387.43