479080-38-1

479080-38-1 structure

479080-38-1 structure

Name: OT antagonist 1
Chemical Name: OT antagonist 1
CAS Number: 479080-38-1
Molecular Formula: C₂₂H₂₂N₄O₃
Molecular Weight: 390.44
Catalog: Signaling Pathways GPCR/G Protein Oxytocin Receptor
Create Date: 2019-02-08 11:23:49
Modify Date: 2024-01-09 13:31:23
OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.

Name	OT antagonist 1

Description	OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor Research Areas >> Endocrinology
Target	Ki: 50 nM (Oxytocin)[1]
In Vitro	Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V1A, V1B and V2. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists[1].
References	[1]. Brown A, et al. Design and optimization of potent, selective antagonists of Oxytocin. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4278-81.

Molecular Formula	C₂₂H₂₂N₄O₃
Molecular Weight	390.44