123134-61-2
123134-61-2 structure
- Name: TMBIM6 antagonist-1
- Chemical Name: BIA
- CAS Number: 123134-61-2
- Molecular Formula: C15H12N2O3
- Molecular Weight: 268.267383575439
- Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
- Create Date: 2020-09-12 18:47:16
- Modify Date: 2024-02-01 08:50:01
-
TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+[1].
| Name | BIA |
|---|---|
| Synonyms | 2-Propen-1-one, 1-(2-aminophenyl)-3-(3-nitrophenyl)- |
| Description | TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TMBIM6 antagonist-1 (BIA, 0.5-10 μM, 3 days) significantly and dose-dependently inhibits cell viability in HT1080, MCF7, MDA-MB-2341 and SKBR3 cells, with IC50 values of 1.7 ± 0.1 μM for HT1080, 2.6 ± 0.4 μM for MCF cells, 2.6 ± 0.5 μM for MDA-MB-231 cells, and 2.4 ± 0.4 μM for SKBR3 cells, respectively[1]. TMBIM6 antagonist-1 (BIA, 10 μM) treatment decreases cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells, not TMBIM6 KO HT1080 cells[1]. Cell Viability Assay[1] Cell Line: HT1080, MCF7, MDA-MB-2341 and SKBR3 cells. Concentration: 0.5-10 μM. Incubation Time: 3 days. Result: Inhibited cell viability. Western Blot Analysis[1] Cell Line: WT and TMBIM6 KO HT1080 cells. Concentration: 0, 2, 5 μM. Incubation Time: Result: Downregulated the protein levels of AKT-pS473. |
| In Vivo | TMBIM6 antagonist-1 (1 mg/kg, IP 5 days per week during 25 days) significantly impaires cell-driven tumor growth[1]. Animal Model: Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells)[1]. Dosage: 1 mg/kg. Administration: IP 5 days per week during 25 days. Result: Impaired cell-driven tumor growth. |
| References |
| Molecular Formula | C15H12N2O3 |
|---|---|
| Molecular Weight | 268.267383575439 |
| Storage condition | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |