1221416-42-7
1221416-42-7 structure
- Name: Relenopride hydrochloride
- Chemical Name: 97CC34KNCU
- CAS Number: 1221416-42-7
- Molecular Formula: C24H31Cl2FN4O4
- Molecular Weight: 529.432
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-06-22 05:42:38
- Modify Date: 2025-08-21 08:31:23
-
Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A (Ki=600 nM) and 5-HT2B receptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility[1][2].
| Name | 97CC34KNCU |
|---|---|
| Synonyms |
(1S)-3-(4-{[(4-Amino-5-chloro-2-methoxybenzoyl)amino]methyl}-1-piperidinyl)-1-(4-fluorophenyl)propyl carbamate hydrochloride (1:1)
97CC34KNCU RELENOPRIDE HYDROCHLORIDE Benzamide, 4-amino-N-[[1-[(3S)-3-[(aminocarbonyl)oxy]-3-(4-fluorophenyl)propyl]-4-piperidinyl]methyl]-5-chloro-2-methoxy-, hydrochloride (1:1) |
| Description | Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A (Ki=600 nM) and 5-HT2B receptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility[1][2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT4 Receptor:4.96 nM (Ki) 5-HT2A Receptor:600 nM (Ki) 5-HT2B Receptor:31 nM (Ki) 5-HT2B Receptor:2.1 μM (IC50) |
| In Vitro | Relenopride hydrochloride do not show any significant off-target binding to any other receptors, enzymes, orserotonin-receptor subtypes at 1 μM, except for binding to the 5-HT2A receptor and the 5-HT2B receptor. Relenopride hydrochloride shows antagonist activity at the 5-HT2B receptor with an IC50 of 2.1 μM and no significant activity at the 5-HT2A receptor up to 10 μM. Relenopride hydrochloride shows no activity against serotonin-receptor subtypes 5-HT1B, 5-HT1D, or 5-HT2A at 1 nM to 10 μM, or for serotonin-receptor subtype 5-HT7 at 10 nM to 30 μM[1]. |
| References |
| Molecular Formula | C24H31Cl2FN4O4 |
|---|---|
| Molecular Weight | 529.432 |
| Exact Mass | 528.170654 |