Relenopride hydrochloride
Modify Date: 2025-08-21 08:31:23
Relenopride hydrochloride structure
|
Common Name | Relenopride hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1221416-42-7 | Molecular Weight | 529.432 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H31Cl2FN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Relenopride hydrochlorideRelenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A (Ki=600 nM) and 5-HT2B receptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility[1][2]. |
| Name | 97CC34KNCU |
|---|---|
| Synonym | More Synonyms |
| Description | Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A (Ki=600 nM) and 5-HT2B receptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility[1][2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT4 Receptor:4.96 nM (Ki) 5-HT2A Receptor:600 nM (Ki) 5-HT2B Receptor:31 nM (Ki) 5-HT2B Receptor:2.1 μM (IC50) |
| In Vitro | Relenopride hydrochloride do not show any significant off-target binding to any other receptors, enzymes, orserotonin-receptor subtypes at 1 μM, except for binding to the 5-HT2A receptor and the 5-HT2B receptor. Relenopride hydrochloride shows antagonist activity at the 5-HT2B receptor with an IC50 of 2.1 μM and no significant activity at the 5-HT2A receptor up to 10 μM. Relenopride hydrochloride shows no activity against serotonin-receptor subtypes 5-HT1B, 5-HT1D, or 5-HT2A at 1 nM to 10 μM, or for serotonin-receptor subtype 5-HT7 at 10 nM to 30 μM[1]. |
| References |
| Molecular Formula | C24H31Cl2FN4O4 |
|---|---|
| Molecular Weight | 529.432 |
| Exact Mass | 528.170654 |
| (1S)-3-(4-{[(4-Amino-5-chloro-2-methoxybenzoyl)amino]methyl}-1-piperidinyl)-1-(4-fluorophenyl)propyl carbamate hydrochloride (1:1) |
| 97CC34KNCU |
| RELENOPRIDE HYDROCHLORIDE |
| Benzamide, 4-amino-N-[[1-[(3S)-3-[(aminocarbonyl)oxy]-3-(4-fluorophenyl)propyl]-4-piperidinyl]methyl]-5-chloro-2-methoxy-, hydrochloride (1:1) |