39537-23-0

39537-23-0 structure

Name: L-Alanyl-L-Glutamine
Chemical Name: (2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoic acid
CAS Number: 39537-23-0
Molecular Formula: C₈H₁₅N₃O₄
Molecular Weight: 217.22
Catalog: Biochemical Amino acids and their derivatives Other protected amino acids
Create Date: 2018-03-07 08:00:00
Modify Date: 2024-01-02 22:59:04
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations[1].

Name	(2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoic acid
Synonyms	UNII-U5JDO2770Z (2S)-2-((2S)-2-Aminopropanoylamino)-4-carbamoylbutanoic acid ZY1&VMYVQ2VZ &&L-L Form glutaminic acid Gln L-Ala-L-Gln EINECS 475-290-9 glutamine L-Gln Pentanoic acid, 2,5-diamino-5-oxo-, (S)- L-Alanyl-L-glutamine Levoglutamide (S)-5-Amino-2-[(S)-2-aminopropanamido]-5-oxopentanoic acid L-Glutamine,L-alanyl 2,5-Diamino-5-oxopentanoic acid, (S)- (2S)-2-amino-4-carbamoylbutanoic acid Alanyl-glutamine,Glutamine-S Ala-Gln 2-Aminoglutaramic acid, L- (S)-(+)-Glutamine 5-Hydroxy-5-imino-L-norvaline N(2)-L-alanyl-L-glutamine Glutamine-S Alanyl-glutamine L-Norvaline, 5-hydroxy-5-imino- L-Glutamic Acid g-Amide L-Glutamic acid γ-amide N-L-alanyl-L-glutamine L-Glutamine, N2-L-alanyl- L-Glutamine l-alanyl-l-glutamin l-(+)-glutamic acid-5-amide L-Glutamic acid 5-amide H-Ala-Gln-OH GLUTAMINE, L- (2S)-5-Amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid L-Glutamine, L-alanyl- MFCD00133046 S(+)-Glutamic acid 5-amide Alanyl glutamine

Description	L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	L-Alanyl-L-glutamine (2 mM; 24 hours) partially or fully attenuates chronic insulin secretion, and IR-β and COX IV levels which are decreased when β-cells were exposed to macrophages following stimulation in vitro (IMMs)[1]. L-Alanyl-L-glutamine -dependent β-cell protection mediated by coordinated effects on the glutamine-GSH axis, and the HSP pathway, maintenance of mitochondrial metabolism and stimulus-secretion coupling essential for insulin release[1].
References	[1]. Cruzat VF,et al. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. J Endocrinol. 2015 Mar;224(3):261-71.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S23-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	1
HS Code	2924199090

56-85-9

1142-20-7

~64%

39537-23-0

Literature: Zhao, Yufen; Tang, Guo; Zhou, Ning; Hu, Liming; Chen, Yong Patent: US2005/233977 A1, 2005 ; Location in patent: Page/Page column 4-5 ;

56-85-9

5872-22-0

~50%

39537-23-0

Literature: Zhao, Yufen; Tang, Guo; Zhou, Ning; Hu, Liming; Chen, Yong Patent: US2005/233977 A1, 2005 ; Location in patent: Page/Page column 4 ;

21467-17-4

39537-23-0

Literature: Otsuka Pharmaceutical Co., Ltd. Patent: US4474754 A1, 1984 ;

4652-65-7

39537-23-0

Literature: Shimonishi,Y. Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 200 - 203

96789-24-1

39537-23-0

Literature: Shimonishi,Y. Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 200 - 203

910908-63-3

39537-23-0

Literature: Shimonishi,Y. Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 200 - 203

101896-82-6

39537-23-0

Literature: Shimonishi,Y. Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 200 - 203

90770-50-6

39537-23-0

Literature: Shimonishi,Y. Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 200 - 203

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%