170116-63-9

170116-63-9 structure

Name: Z-Pro-Pro-aldehyde-dimethyl acetal
Chemical Name: Benzyl (2S)-2-{[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl}-1-pyrrolidinecarboxylate
CAS Number: 170116-63-9
Molecular Formula: C₂₀H₂₈N₂O₅
Molecular Weight: 376.447
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-29 22:59:27
Modify Date: 2024-01-19 11:23:18
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].

Name	Benzyl (2S)-2-{[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl}-1-pyrrolidinecarboxylate
Synonyms	Benzyl (2S)-2-{[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl}-1-pyrrolidinecarboxylate 1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-

Description	Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].
Related Catalog	Research Areas >> Neurological Disease
Target	PREP:12 nM (IC50)
References	[1]. Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. [2]. Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85.