1347760-82-0

1347760-82-0 structure

Name: Propargyl-PEG3-acid
Chemical Name: 3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid
CAS Number: 1347760-82-0
Molecular Formula: C₁₀H₁₆O₅
Molecular Weight: 216.231
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-04-17 16:33:39
Modify Date: 2024-01-06 19:40:44
Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid[1].

Name	3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid
Synonyms	Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- 3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid

Description	Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377. [2]. Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.