91-80-5
91-80-5 structure
- Name: Methapyrilene
- Chemical Name: methapyrilene
- CAS Number: 91-80-5
- Molecular Formula: C14H19N3S
- Molecular Weight: 261.38600
- Catalog: Natural product Flavonoids
- Create Date: 2018-08-31 11:56:28
- Modify Date: 2025-08-26 19:25:32
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Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
| Name | methapyrilene |
|---|---|
| Synonyms |
Restryl
Thenylpyramine N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine Paradormalene Methapyrilen Semikon Pyrinistol Thionylan Pyrinistab Thenylene metapyrilene Tenalin |
| Description | Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1]. |
| In Vivo | Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2]. Animal Model: Male Wistar derived AlpK:APfSD (Alderley Park) rats[2] Dosage: 50 mg/kg, 150 mg/kg Administration: Gavage with water (vehicle), daily, 3 days Result: Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg. Decreased levels of both glucose and glycogen in the liver. Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg. |
| Boiling Point | 173 - 175ºC at 3 mm Hg |
|---|---|
| Molecular Formula | C14H19N3S |
| Molecular Weight | 261.38600 |
| Exact Mass | 261.13000 |
| PSA | 47.61000 |
| LogP | 2.71130 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| RIDADR | UN 1851 |
|---|---|
| Packaging Group | III |
| Hazard Class | 6.1(b) |