1043495-96-0

1043495-96-0 structure

Name: RO 5256390
Chemical Name: 2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-
CAS Number: 1043495-96-0
Molecular Formula: C₁₃H₁₈N₂O
Molecular Weight: 218.295
Catalog: Research Areas Neurological Disease
Create Date: 2018-02-25 11:21:42
Modify Date: 2024-01-14 21:05:07
RO5256390 is an agonist of trace amine-associated receptor 1 (TAAR1), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines.RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system[1].RO5256390 is a modulator of monoaminergic neurotransmission, blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties[2].

Name	2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-
Synonyms	(4S)-4-[(2S)-2-Phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine (S)-4-((S)-2-Phenylbutyl)-4,5-dihydrooxazol-2-amine (S)-4-((S)-2-Phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine 2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-

Description	RO5256390 is an agonist of trace amine-associated receptor 1 (TAAR1), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines.RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system[1].RO5256390 is a modulator of monoaminergic neurotransmission, blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470. [2]. Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56.