RO 5256390

Modify Date: 2024-01-14 21:05:07

RO 5256390 structure	Common Name	RO 5256390
	CAS Number	1043495-96-0	Molecular Weight	218.295
	Density	1.1±0.1 g/cm3	Boiling Point	330.9±25.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₈N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	153.9±23.2 °C

Use of RO 5256390

RO5256390 is an agonist of trace amine-associated receptor 1 (TAAR1), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines.RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system[1].RO5256390 is a modulator of monoaminergic neurotransmission, blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties[2].

Name	2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-
Synonym	More Synonyms

Description	RO5256390 is an agonist of trace amine-associated receptor 1 (TAAR1), a highly conserved G-protein-coupled receptor (GPCR) bound by endogenous trace amines.RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system[1].RO5256390 is a modulator of monoaminergic neurotransmission, blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470. [2]. Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470.

[2]. Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56.

Density	1.1±0.1 g/cm3
Boiling Point	330.9±25.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₈N₂O
Molecular Weight	218.295
Flash Point	153.9±23.2 °C
Exact Mass	218.141907
LogP	2.85
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.576

(4S)-4-[(2S)-2-Phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine

(S)-4-((S)-2-Phenylbutyl)-4,5-dihydrooxazol-2-amine

(S)-4-((S)-2-Phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine

2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-

DC Chemicals Limited
China
Product Name: RO 5256390
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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