1422144-42-0

1422144-42-0 structure

Name: Netarsudil mesylate
Chemical Name: Netarsudil mesylate
CAS Number: 1422144-42-0
Molecular Formula: C₃₀H₃₅N₃O₉S₂
Molecular Weight: 645.744
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2018-02-13 21:51:04
Modify Date: 2024-01-02 18:29:38
Netarsudil mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.

Name	Netarsudil mesylate
Synonyms	Netarsudil mesylate 4-[(2S)-3-Amino-1-(6-isoquinolinylamino)-1-oxo-2-propanyl]benzyl 2,4-dimethylbenzoate methanesulfonate (1:2) Methansulfonsäure --4-[(2S)-3-amino-1-(6-isochinolinylamino)-1-oxo-2-propanyl]benzyl-2,4-dimethylbenzoat (2:1) Acide méthanesulfonique - 2,4-diméthylbenzoate de 4-[(2S)-3-amino-1-(6-isoquinoléinylamino)-1-oxo-2-propanyl]benzyle (2:1) Benzoic acid, 2,4-dimethyl-, [4-[(1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenyl]methyl ester, methanesulfonate (1:2) AR-13324 (mesylate)

Description	Netarsudil mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK Research Areas >> Others
References	[1]. Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4. [2]. Levy B, et al. Ocular hypotensive safety and systemic absorption of AR-13324 ophthalmic solution in normal volunteers. Am J Ophthalmol. 2015 May;159(5):980-5.e1.