Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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Email: enquiry@dycnchem.com

67401-56-3

67401-56-3 structure

Name: Micrococcin P1
Chemical Name: micrococcin P1
CAS Number: 67401-56-3
Molecular Formula: C₄₈H₄₉N₁₃O₉S₆
Molecular Weight: 1144.37000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-10 09:10:33
Modify Date: 2024-01-10 07:41:33
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM[1]. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively[2]. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum[3].

Name	micrococcin P1

Description	Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM[1]. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively[2]. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum[3].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	HCV[1]; Bacterial[2]; Parasite[3]
In Vitro	Dose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC80 of about 1 mM with potency comparable with that of isoniazid[1].
References	[1]. Lee M, et al. Micrococcin P1, a naturally occurring macrocyclic peptide inhibiting hepatitis C virus entry in a pan-genotypic manner. Antiviral Res. 2016 Aug;132:287-95. [2]. Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975. [3]. Carnio MC, et al. Pyridinyl polythiazole class peptide antibiotic micrococcin P1, secreted by foodborne Staphylococcus equorum WS2733, is biosynthesized nonribosomally. Eur J Biochem. 2001 Dec;268(24):6390-401.

Molecular Formula	C₄₈H₄₉N₁₃O₉S₆
Molecular Weight	1144.37000
Exact Mass	1143.21000
PSA	494.96000
LogP	7.66500

Hazard Codes	Xi

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